1CP-LSD 100mcg Blotters
1CP-LSD 100mcg Blotters History
1CP-LSD 100mcg Blotters or 1-Cyclopropionyl-d-lysergic acid diethylamide (also known as 1cP-LSD) is a lesser-known novel psychedelic substance of the lysergamide class. It is chemically similar to LSD and other LSD analogs like 1B-LSD, ALD-52, and 1P-LSD. Its mechanism of action is not well-studied, but is thought to produce its effects via stimulation of serotonin receptors in parts of the brain.
The origins of 1cP-LSD are not well-documented. Limited data exist on the pharmacology, metabolism, and toxicity of 1cP-LSD. While it is presumed to have a similar risk profile as LSD and its analogs, which are generally thought to be safe in controlled settings, more research is needed.
WE in no way condoned Vivo experimentation here at FXchemlabs. We explicitly ban the use of Vivo experimentation whether on Humans or veterinary experimentation
1CP-LSD 100mcg Blotters are a semisynthetic compound of the lysergamide family. It is similar to LSD and is named for the cyclopropionyl group bound to the nitrogen of the polycyclic indole group of LSD. The cyclopropionyl group consists of a carbonyl ring with the chemical formula C3H6 bound to an amino group. The structure of 1cP-LSD contains a polycyclic group featuring a bicyclic hexahydro indole bound to a bicyclic quinoline group. At carbon 8 of the quinoline, an N,N-diethyl carboxamide is bound.
The properties of the substance 1cP-LSD are described as almost identical to those of the classic LSD 25 and 1P-LSD. However, an alkylcarbonyl group has the empirical formula C4H7O, whereas the cyclopropylcarbonyl group corresponds to a molecular formula of C4H5O. Accordingly, one can not call the cyclopropyl as alkyl radical and thus the substance 1cP-LSD is not affected by the NpSG amending Regulation. Learn More
Based on its structural similarity to LSD, 1cP-LSD likely acts as a partial agonist at the 5-HT2A receptor. The psychedelic effects are thought to primarily come from its efficacy at the 5-HT2A receptors distributed throughout the brain. 1cP-LSD also likely displays binding activity at a wide range of monoamine receptors, such as those for dopamine and norepinephrine. However, there is currently no data to support these claims.
Most serotonergic psychedelics are not significantly dopaminergic, and 1-cP-LSD is therefore atypical in this regard. The agonism of the D2 receptor may contribute to its psychoactive effects in humans. 1cP-LSD binds to most serotonin receptor subtypes except for the 5-HT3 and 5-HT4 receptors. However, most of these receptors are affected at too low affinity to be sufficiently activated by the brain concentration of approximately 10–20 nM. Recreational doses can affect 5-HT1A (Ki=1.1nM), 5-HT2A (Ki=2.9nM), 5-HT2B (Ki=4.9nM), 5-HT2C (Ki=23nM), 5-HT5A (Ki=9nM [in cloned rat tissues]), and 5-HT6 receptors (Ki=2.3nM).
1cP-LSD is a biased agonist that induces a conformation in serotonin receptors that preferentially recruits β-arrestin over activating G proteins. A crystal structure of 5-HT2B bound to 1cP-LSD reveals an extracellular loop that forms a lid over the diethylamide end of the binding cavity which explains the slow rate of unbinding from serotonin receptors. Learn More