25C-NBOH (2C-C-NBOH)
Forensic and Analytical Overview
1. Chemical Identification
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Common name: 25C-NBOH
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Systematic name: 2-(4-Chloro-2,5-dimethoxyphenyl)-N-[(2-hydroxybenzyl)]ethanamine
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Chemical class: Substituted phenethylamine (NBOH series)
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Molecular formula: C₁₇H₂₀ClNO₃
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Molecular weight: ≈321.8 g/mol
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Structural relation: N-hydroxybenzyl analogue of 2C-C; closely related to the NBOMe and 25-series compounds.
2. Background
25C-NBOH belongs to the NBOH family of compounds derived from the 2C series of substituted phenethylamines.
It was first described in analytical literature in the 2010s during investigations of novel psychoactive substances (NPS) and remains a subject of interest in toxicology and forensic chemistry.
25C-NBOH has no medical use and is controlled in most jurisdictions because of its potent pharmacological activity.
3. Analytical Characterization
Laboratory identification commonly involves:
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Gas Chromatography–Mass Spectrometry (GC–MS)
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Liquid Chromatography–Mass Spectrometry (LC–MS or LC-QTOF)
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Infrared (IR) spectroscopy for functional group verification
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Nuclear Magnetic Resonance (NMR) for structural confirmation
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High-resolution mass spectrometry (HRMS) for isomer differentiation
Characteristic fragments associated with the hydroxybenzyl group help confirm identity and distinguish it from 25I-, 25B-, or 25E-NBOH analogues.
4. Research and Forensic Relevance
25C-NBOH is primarily referenced in:
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Forensic casework involving seized samples and toxicological screens
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Analytical method development and inter-laboratory validation
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Comparative SAR studies of substituted phenethylamines
These data contribute to the wider body of research on NPS detection and analytical standardization.
5. Legal and Safety Notes
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Regulatory status: Controlled or scheduled in many countries.
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Use restriction: For authorized analytical or forensic laboratories only.
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Safety: Handle in compliance with hazardous chemical regulations; use appropriate PPE and disposal procedures.
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Storage: Store securely in a cool, dry, and light-protected environment.
6. Summary
25C-NBOH is a forensically relevant phenethylamine derivative used as a reference material in the detection and study of emerging psychoactive substances.
Its documentation aids analytical laboratories and regulatory bodies in tracking and identifying compounds within the NBOH/NBOMe family.
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